Polycyclic heterocycles with acidic N-H group. Part VI. The synthesis of some polycyclic heterocyclic compounds related to 3-phenyl-1,2-dihydroquinoxalin-2-one was written by Frysova, Iveta;Slouka, Jan;Gucky, Tomas. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2005.Formula: C8H4N2O4 This article mentions the following:
This work deals with the study of the reactivity of substituted 3-(2-aminophenyl)-1,2-dihydroquinoxalin-2-ones. 3-(2-Amino-4-fluorophenyl)-1,2-dihydroquinoxalin-2-one (I) was prepared by the reaction of 6-fluoro-N-acetylisatin with 1,2-diaminobenzene and further hydrolysis of the acetyl group. The resp. 3-(2-amino-3-nitrophenyl) compound (II) was prepared directly by the reaction of 7-nitroisatin with 1,2-diaminobenzene. Subsequent cyclization of I and II in POCl3 afforded the corresponding indolo[2,3-b]quinoxalines. Intramol. splitting cyclizations of diazonium salts derived from I and II led to [1]benzofuro[2,3-b]quinoxalines and azo-coupling reactions of the diazonium salts with Et cyanoacetylcarbamate and malonodinitrile gave arylhydrazones. These arylhydrazones were then transformed into 1,3-diaminopyrazoles and 6-azauracils. In the experiment, the researchers used many compounds, for example, 7-Nitroindoline-2,3-dione (cas: 112656-95-8Formula: C8H4N2O4).
7-Nitroindoline-2,3-dione (cas: 112656-95-8) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Formula: C8H4N2O4
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles