Fu, Li Qiang published the artcileSynthesis and antibacterial activity of pleuromutilin derivatives with novel C(14) side chain, Recommanded Product: 4-Hydroxy-2,3-dihydroisoindol-1-one, the main research area is pleuromutilin derivative synthesis antibacterial agent.
In order to find novel antibacterial agents with superior antibacterial activity and overcoming multidrug resistance, a series of pleuromutilin derivatives with novel C(14) side chain were synthesized and evaluated for their in vitro antibacterial activities. The results of antibacterial activities indicated that most of the derivatives showed potent activities against Gram-pos. organisms. In particular, compound I exhibited the most potent inhibitory activity compared with pleuromutilin and linezoid, emerged as potential mol. for further investigation.
Chinese Chemical Letters published new progress about Antibacterial agents. 366453-21-6 belongs to class indole-building-block, name is 4-Hydroxy-2,3-dihydroisoindol-1-one, and the molecular formula is C8H7NO2, Recommanded Product: 4-Hydroxy-2,3-dihydroisoindol-1-one.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles