Synthesis of Rucaparib-a poly (ADP-ribose) polymerase inhibitor was written by Geng, Yuan-shuo;Hu, Po;Wang, Xin;Liu, Chao;Li, Zhi-yu. And the article was included in Jingxi Huagong Zhongjianti in 2012.Safety of 8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one phosphate This article mentions the following:
Rucaparib is the first poly(ADP-ribose) polymerase (PARP) inhibitor which entered into the clin. trial. It was prepared in 5.38% overall yield in 12 steps by using 5-fluoro-2-methylbenzoic acid as the starting material. The synthetic process was designed as a novel method with less toxicity and easy operation. The structures of the intermediates and the final product were identified with MS and 1H NMR. In the experiment, the researchers used many compounds, for example, 8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one phosphate (cas: 459868-92-9Safety of 8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one phosphate).
8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one phosphate (cas: 459868-92-9) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Safety of 8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one phosphate
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Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles