An article Poly(amine-co-ester)s by Binary Organocatalytic Ring-Opening Polymerization of N-Boc-1,4-oxazepan-7-one: Synthesis, Characterization, and Self-Assembly WOS:000507721500025 published article about POLY(BETA-AMINO ESTER)S; ALIPHATIC POLYESTERS; IN-VITRO; GENE; DELIVERY; DESIGN; DNA; NANOPARTICLES; TRANSPORTERS; POLYCATIONS in [Wang, Xin; Hadjichristidis, Nikos] KAUST, Phys Sci & Engn Div, KAUST Catalysis Ctr, Polymer Synth Lab, Thuwal 23955, Saudi Arabia in 2020.0, Cited 52.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Safety of Benzyl Alcohol
Binary organocatalytic ring-opening polymerization (ROP) of N-Boc-1,4-oxazepan-7-one (OxP(BOC)) is proposed as a versatile method to generate metal-free poly(amine-co-ester)s and the corresponding biodegradable polycationic homo/block (co)polymers. Optimization experiments with different organocatalysts, including 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD), DBU/1-(3,5-bis(trifluoromethyl)phenyl)-3-cyclohexylthiourea (TU1), and phosphazene/thiourea, revealed that t-Bu-P-4/TU1 leads to a fast and controlled/living ROP with benzyl alcohol (BnOH) as an initiator and thus allows the formation of well-defined poly(amine-co-ester)s with high molecular mass (M-n,M-SEC up to 38.8 kg mol(-1)) and narrow dispersity. Well-defined poly(N-Boc-1,4-oxazepan-7-one)-based diblock copolymers were also synthesized successfully via the controlled/living ROP, regardless of whether hydrophilic poly(ethylene glycol) (PEG) or hydrophobic polycaprolactone (PCL) was used as a macroinitiator. After treatment with trifluoroacetic acid, the corresponding water-soluble polycationic homopolymer, as well as the hydrophilic (PEG -based copolymer) and amphiphilic (PCL-based copolymer) polycationic diblock copolymers, was obtained. Dynamic light scattering in water and transmission electron microscopy analyses revealed that both polycationic copolymers self-assembled spontaneously to nanostructures; the hydrophilic block copolymer formed spherical nanoparticles, while the amphiphilic one formed rod-shaped nanoparticles.
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