Product Details of 123-11-5. Recently I am researching about CATALYTIC ASYMMETRIC-SYNTHESIS; BETA-LACTONE DIMER; DISUBSTITUTED KETENES; ONE-POT; DERIVATIVES; DIMERIZATION; DIMETHYLKETENE; AMINES, Saw an article supported by the National Science FoundationNational Science Foundation (NSF); National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [CHE-1463728, R15GM107800]. Published in ARKAT USA INC in GAINESVILLE ,Authors: Ibrahim, AA; Harzmann, GD; Nalla, D; Elledge, B; Van Raaphorst, M; Kerrigan, NJ. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde
An investigation of the reaction of heteroatom nucleophiles with ketene dimers, with an emphasis on a discussion of diastereoselectivity where applicable, is described. During this study we focused on the reaction of nitrogen-centred nucleophiles (Weinreb amine, lithiated Weinreb amide, and an amino acid derivative), and oxygen-centred nucleophiles (alkoxides). Simple Weinreb amide derivatives of ketene heterodimers were formed in moderate to excellent yield (up to 89%) and excellent retention of chirality (ee up to 91%), albeit with poor diastereoselectivity. The 2-pyridone-catalysed amine ring-opening was also applied to the asymmetric synthesis of a cinnabaramide A intermediate. Finally, the use of amide and alkoxide ring-opening nucleophiles enabled the development of a sequential one-pot reaction with benzaldehyde to afford delta-lactones in moderate yields (up to 47%) but with good diastereoselectivity (dr up to 24:1). [GRAPHICS]
Product Details of 123-11-5. Welcome to talk about 123-11-5, If you have any questions, you can contact Ibrahim, AA; Harzmann, GD; Nalla, D; Elledge, B; Van Raaphorst, M; Kerrigan, NJ or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles