Giacomelli, Cristiano published the artcileLoading capacity of copolymer micelles enhanced by specific interactions, Safety of 2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-1-morpholinoethanone, the publication is Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) (2007), 48(2), 411-412, database is CAplus.
Block copolymer self-assemblies have been successfully tested in many applications as nanocarriers, especially in drug delivery. We report herein that specific interactions between hydrophobic guest mols. and core-forming segments can improve significantly the loading capacity of polymeric micelles. When selected probes exhibiting weak carboxylic acid groups in their structure were loaded into micellar nanoparticles with poly(dialkylamino)ethyl methacrylate-based cores (i.e., weak polybases), high loadings were usually achieved (> 100 % weight/weight of polymer (w/wp)). The existence of acid-base interactions between the solubilizate and the weak polybase block forming the micelle core was evidenced by 1H NMR measurements, and also through a systematic encapsulation study using structurally different probes and block copolymers.
Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) published new progress about 2854-32-2. 2854-32-2 belongs to indole-building-block, auxiliary class GPCR/G Protein,Cannabinoid Receptor, name is 2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-1-morpholinoethanone, and the molecular formula is C23H23ClN2O4, Safety of 2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-1-morpholinoethanone.
Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles