Girijavallabhan, Vinay M.;Chen, Lei;Dai, Chaoyang;Feltz, Robert J.;Firmansjah, Luke;Li, Dansu;Kim, Seong Heon;Kozlowski, Joseph A.;Lavey, Brian J.;Kosinski, Aneta;Piwinski, John J.;Popovici-Muller, Janeta;Rizvi, Razia;Rosner, Kristin E.;Shankar, Banderpalle B.;Shih, Neng-Yang;Siddiqui, M. Arshad;Tong, Ling;Wong, Michael K. C.;Yang, De-yi;Yang, Liping;Yu, Wensheng;Zhou, Guowei;Guo, Zhuyan;Orth, Peter;Madison, Vincent;Bian, Hong;Lundell, Daniel;Niu, Xiaoda;Shah, Himanshu;Sun, Jing;Umland, Shelby published 《Novel TNF-α converting enzyme (TACE) inhibitors as potential treatment for inflammatory diseases》. The research results were published in《Bioorganic & Medicinal Chemistry Letters》 in 2010.Reference of 6-Methoxyisoindolin-1-one The article conveys some information:
Our research on hydantoin based TNF-α converting enzyme (TACE) inhibitors has led to an acetylene containing series that demonstrates sub-nanomolar potency (K i) as well as excellent activity in human whole blood. These studies led to the discovery of highly potent TACE inhibitors such as 37 (I) with good DMPK profiles. The experimental procedure involved many compounds, such as 6-Methoxyisoindolin-1-one (cas: 132680-54-7) .
6-Methoxyisoindolin-1-one(cas:132680-54-7 Reference of 6-Methoxyisoindolin-1-one) also interacts with inhibitors of other topoisomerases such as camptothecin and etoposide. It has been shown that combining these two drugs can inhibit cancer cells more effectively than either drug alone.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles