Synthesis and biological activities of indole-3-propionic acids was written by Girisha, M.;Badiger, Jaishree;Purohit, M. G.;Thippeswamy, B. S.;Patil, B. M.. And the article was included in Indian Journal of Heterocyclic Chemistry in 2008.Synthetic Route of C14H10ClN This article mentions the following:
Treatment of 2,5-substituted indoles with acrylic acid in presence of acetic acid and acetic anhydride yielded the desired 2,5-substituted indole-3-propionic acids. The structures of compounds were confirmed by IR, NMR and mass spectral data. The newly synthesized compounds were screened for their antiinflammatory activity and analgesic activity. All the compounds of this series showed promising antiinflammatory and analgesic activity. The most active compound of this series was 2-ethoxycarbonyl-5-methylindole-3-propionic acid. It was most potent which showed higher percent of inhibition of edema and analgesia. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-phenyl-1H-indole (cas: 23746-76-1Synthetic Route of C14H10ClN).
5-Chloro-2-phenyl-1H-indole (cas: 23746-76-1) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Synthetic Route of C14H10ClN
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles