Golovko, T. V. published the artcileNew synthesis of pyrido[4,3-b]indoles (γ-carbolines) on the basis of indolin-2-one lactim ether, Category: indole-building-block, the main research area is indolinone lactim ether malononitrile condensation; oxindole lactim ether malononitrile condensation; pyridoindole preparation; gamma carboline preparation; pyrimidocarboline preparation.
Condensation of indolin-2-one (oxindole) lactim ether with H2C(CN)2 leads to 2-dicyanomethylidene-2,3-dihydroindole. Subsequent reaction with DMF di-Et acetal [or HC(OEt)3] and further cyclization affords 4-cyanopyrido[4,3-b]indoles (γ-carbolines). 3-Amino-4-cyanopyrido[4,3-b]indole was used in the synthesis of substituted pyrimido[4,5-c]-γ-carbolines.
Russian Chemical Bulletin published new progress about Condensation reaction. 1009-27-4 belongs to class indole-building-block, name is 2-Ethoxy-1H-indole, and the molecular formula is C10H11NO, Category: indole-building-block.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles