Gomes, Joao R. published the artcileBDNF-Induced Intracellular Signaling, Product Details of C19H21N3O3S, the publication is Neuromethods (2019), 161-183, database is CAplus.
The neurotrophin BDNF plays important roles in neuronal survival, growth, and differentiation during development. Furthermore, it has been shown to mediate long-term changes in the synaptic activity in the hippocampus and in other brain regions, which are thought to underlie learning and memory formation. Cultured hippocampal neurons express TrkB receptors and, therefore, constitute a valuable exptl. model to study in vitro BDNF-induced intracellular signaling pathways. In this chapter, we describe (1) the methodol. used to prepare cultured hippocampal neurons from mice (wild-type-WT or transgenic animals) and rats and (2) three different approaches to investigate BDNF signaling: Western blot and Bio-Plex for overall signaling activity and immunocytochem. to analyze where signaling activity takes place in neurons. The Bio-Plex approach allows the simultaneous characterization of different pathways using small sample volumes and within a short period of time.
Neuromethods published new progress about 330161-87-0. 330161-87-0 belongs to indole-building-block, auxiliary class Protein Tyrosine Kinase/RTK,Src, name is SU6656, and the molecular formula is C19H21N3O3S, Product Details of C19H21N3O3S.
Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles