Analysis of indole acid derivatives by gas chromatography using liquid phase OV-101 was written by Grunwald, Claus;Lockard, R. G.. And the article was included in Journal of Chromatography in 1970.Quality Control of 3-(1H-Indol-1-yl)propanoic acid This article mentions the following:
One stationary phase (OV-101, a dimethylsiloxane polymer) and 2 derivatives (Me esters and trimethylsilyl derivatives) resolved 9 or 10 closely related acidic indoles at the 99% level. This is better resolution than has been obtained with other stationary phases. Bis(trimethylsilyl)-trifluoroacetamide was more effective than bis(trimethylsilyl)-acetamide as a reagent for producing trimethylsilyl derivatives The column was packed with 80-90 mesh Anakrom ABS coated with 5% OV-101. The carrier gas was He. The column temperature was 200掳; the flash heater and flame ionization detector, 250掳. The relative retention values, compared to ethyl indole-3-acetate, varied from 0.72 to 6.31 for the trimethylsilyl derivatives and from 0.18 to 4.73 for the Me ester derivatives In the experiment, the researchers used many compounds, for example, 3-(1H-Indol-1-yl)propanoic acid (cas: 6639-06-1Quality Control of 3-(1H-Indol-1-yl)propanoic acid).
3-(1H-Indol-1-yl)propanoic acid (cas: 6639-06-1) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Quality Control of 3-(1H-Indol-1-yl)propanoic acid
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles