Guan, Dongliang; Rahman, Toufiqur Md; Gay, Elaine A.; Vasukuttan, Vineetha; Mathews, Kelly M.; Decker, Ann M.; Williams, Alexander H.; Zhan, Chang-Guo; Jin, Chunyang published the artcile< Indole-Containing Amidinohydrazones as Nonpeptide, Dual RXFP3/4 Agonists: Synthesis, Structure-Activity Relationship, and Molecular Modeling Studies>, Safety of 4-Methyl-1H-indole-3-carbaldehyde, the main research area is indole amidinohydrazone preparation SAR mol modeling RXFP3 RXFP4 agonist.
Herein, the first structure-activity relationship studies of a series of novel nonpeptide amidinohydrazone-based agonists I [R1 = H, 4-Me, 7-F, etc.; R2 = H, Me; R3 = ; 4-ClC6H4, 3,4-di-ClC6H3, 2-thienyl, etc.; R4 = H, Me; n = 0,1,2,3], which were characterized by RXFP3 functional and radioligand binding assays was reported. Several potent and efficacious RXFP3 agonists compound I [R1 = 5-CN-7-Me, R2 = H, R3 = 4-CO2MeC6H4, R4 = H, n = 2] were identified with EC50 values <10 nM. These compounds also had high potency at RXFP4 but no agonist activity at RXFP1, demonstrating > 100-fold selectivity for RXFP3/4 over RXFP1. In vitro ADME and pharmacokinetic assessments revealed that the amidinohydrazone derivatives might have limited brain permeability.
Journal of Medicinal Chemistry published new progress about Amidrazones Role: PAC (Pharmacological Activity), PKT (Pharmacokinetics), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation). 4771-48-6 belongs to class indole-building-block, and the molecular formula is C10H9NO, Safety of 4-Methyl-1H-indole-3-carbaldehyde.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles