《Synthesis of β-D-mannosides from β-D-glucosides via an intramolecular SN2 reaction at C-2》 was written by Guenther, Wolfgang; Kunz, Horst. Category: indole-building-block And the article was included in Carbohydrate Research on April 10 ,1992. The article conveys some information:
The selective synthesis of β-D-mannosides was achieved by first synthesizing β-D-glucosides, e.g., I, that carry an N-phenylcarbamoyl protecting group at O-3. These derivatives were transformed into the corresponding β-D-mannosides by intramol. nucleophilic substitution with inversion of configuration at C-2, the O-triflyl group being the leaving group. Subsequent intramol. attack of the neighboring carbamoyl group resulted in the formation of the 2,3-carbonate of the desired β-D-mannoside, e.g., II.Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside(cas: 99409-32-2Category: indole-building-block) was used in this study.
Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside(cas: 99409-32-2) belongs to indole.The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Category: indole-building-blockThey are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles