Optimization, Structure-Activity Relationship, and Mode of Action of Nortopsentin Analogues Containing Thiazole and Oxazole Moieties was written by Guo, Jincheng;Hao, Yanan;Ji, Xiaofei;Wang, Ziwen;Liu, Yuxiu;Ma, Dejun;Li, Yongqiang;Pang, Huailin;Ni, Jueping;Wang, Qingmin. And the article was included in Journal of Agricultural and Food Chemistry in 2019.Computed Properties of C9H5BrN2 This article mentions the following:
Plant diseases seriously endanger plant health, and it is very difficult to control them. A series of nortopsentin analogs were designed, synthesized, and evaluated for their antiviral activities and fungicidal activities. Most of these compounds displayed higher antiviral activities than ribavirin. Compounds (CAS 224434-76-8, 265110-91-6, 272104-33-3), with excellent antiviral activities, emerged as novel antiviral lead compounds, among which compound (CAS 265110-91-6) was selected for further antiviral mechanism research. The mechanism research results indicated that these compounds may play an antiviral role by aggregating viral particles to prevent their movement in plants. Further fungicidal activity tests revealed that nortopsentin analogs displayed broad-spectrum fungicidal activities. Compounds (CAS 2376842-39-4 and 2376840-03-6) displayed higher antifungal activities against Alternaria solani than the com. fungicides carbendazim and chlorothalonil. Current research has laid a foundation for the application of nortopsentin analogs in plant protection. In the experiment, the researchers used many compounds, for example, 5-Bromo-3-cyanoindole (cas: 90271-86-6Computed Properties of C9H5BrN2).
5-Bromo-3-cyanoindole (cas: 90271-86-6) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Computed Properties of C9H5BrN2
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles