Highly Enantioselective Synthesis of (R)-3-Alkyl-3-hydroxyindolin-2-ones including Natural Product (R)-Convolutamydine A Catalyzed by a Primary Amine was written by Guo, Jun-Tao;Zhang, Bao-Qiang;Luo, Yuan;Guan, Zhi;He, Yan-Hong. And the article was included in Asian Journal of Organic Chemistry in 2017.HPLC of Formula: 20780-72-7 This article mentions the following:
An efficient strategy for constructing (R)-3-alkyl-3-hydroxyindolin-2-one derivatives I (R1 = H, 4-Cl, 5-Br, etc.; R2 = H, CH3, Bn) catalyzed by a structurally simple and easily prepared primary amine catalyst under mild conditions has been developed. Various isatins and ketones were tolerated, and the desired products were obtained in up to 99 % yield and up to 99 % ee. The biol. active natural product (R)-convolutamydine A was synthesized in 96 % yield and 95 % ee. In the experiment, the researchers used many compounds, for example, 4-Bromoindoline-2,3-dione (cas: 20780-72-7HPLC of Formula: 20780-72-7).
4-Bromoindoline-2,3-dione (cas: 20780-72-7) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). HPLC of Formula: 20780-72-7
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles