On February 10, 2000, Gwaltney, Stephen L., II; Jae, Hwan-Soo; Kalvin, Douglas M.; Liu, Gang; Sham, Hing L.; Li, Qun; Claiborne, Akiyo K.; Wang, Le; Barr, Kenneth J.; Woods, Keith W. published a patent.Safety of 6-Chloro-1H-indole-5-carboxylic acid The title of the patent was Preparation of substituted oxazolines as antiproliferative agents. And the patent contained the following:
The title compounds [I; R1-R3 = alkyl, alkoxy, thioalkoxy; R4, R5 = H, alkyl; R6 = (un)substituted aryl, heterocyclyl, cycloalkyl, etc.], useful for treating cancer, were prepared E.g., a multi-step synthesis of I [R1-R3 = 3,4,5-(MeO)3; R4, R5 = H; R6 = 4-Me2NC6H4] which showed 100% inhibition in both 48-h cellular proliferation assays that used human colon adenocarcinoma, MDR pos. and human lung cell carcinoma, MDR neg., was given. The experimental process involved the reaction of 6-Chloro-1H-indole-5-carboxylic acid(cas: 256935-86-1).Safety of 6-Chloro-1H-indole-5-carboxylic acid
The Article related to oxazoline preparation antiproliferative antitumor, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Safety of 6-Chloro-1H-indole-5-carboxylic acid
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles