Harada, Hiroshi; Hirokawa, Yoshimi; Suzuki, Kenji; Hiyama, Yoichi; Oue, Mayumi; Kawashima, Hitoshi; Yoshida, Naoyuki; Furutani, Yasuji; Kato, Shiro published the artcile< Novel and potent human and rat β3-adrenergic receptor agonists containing substituted 3-indolylalkylamines>, Name: 4-Methyl-1H-indole-3-carbaldehyde, the main research area is indolylalkylamine preparation adrenergic agonist.
A novel series of 2-(3-indolyl)alkylamino-1-(3-chlorophenyl)ethanols was prepared and evaluated for in vitro ability to stimulate cAMP production in Chinese hamster ovary cells expressing cloned human β3-adrenergic receptor (AR). The optically active I was found to be the most potent and selective human β3-AR agonist in this series with an EC50 value of 0.062 nM. In addition, the selectivity of I for human β3-AR was 210-fold and 103-fold that for human β2-AR and β1-AR, resp. Furthermore, I showed potent agonistic activity at rat β3-AR.
Bioorganic & Medicinal Chemistry Letters published new progress about Aryl aldehydes, heteroaryl Role: RCT (Reactant), RACT (Reactant or Reagent). 4771-48-6 belongs to class indole-building-block, and the molecular formula is C10H9NO, Name: 4-Methyl-1H-indole-3-carbaldehyde.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles