L-Proline/K2CO3-Catalyzed Eco-friendly Synthesis of Novel 2-(1H-Indol-3-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one Derivatives was written by Hari Krishna Reddy, V.;Prashanth Reddy, G.;Krishna Mohan, T.;Venkateswara Rao, A.. And the article was included in Russian Journal of Organic Chemistry in 2021.Quality Control of 5-Chloroindole-3-carboxaldehyde This article mentions the following:
Abstract: A green and eco-friendly synthesis of novel 2-(1H-indol-3-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one derivatives have been developed using L-proline as a simple catalyst. Two efficient methods have been described for the synthesis of dihydroquinazolin-4(1H)-one derivatives In the first method, 1H-1,3-benzoxazine-2,4-dione reacted with substituted anilines and 1H-indole-3-carbaldehydes in water in the presence of L-proline as a catalyst, whereas in the second method, a similar reaction using 1H-indol-3-ylmethanol instead of indole-3-carbaldehyde was catalyzed by L-proline/K2CO3 at room temperature for 30 min to afford the same products. These two protocols involve eco-friendly and inexpensive catalysts and produce the target products in excellent yields with a sufficient purity, so that there was no need of column chromatog. for their isolation or purification In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Quality Control of 5-Chloroindole-3-carboxaldehyde).
5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Quality Control of 5-Chloroindole-3-carboxaldehyde
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles