Harrison, Darwin Anil published the artcileSynthesis and antifungal activity of 1-aminomethyl-3-(p-tolylthiosemicarbazono)-4,5/5,6-dichloroindolin-2-ones, Synthetic Route of 1677-47-0, the main research area is thiosemicarbazide indolinedione amine formaldehyde condensation Mannich aminomethylation; aminomethyl thiosemicarbazonoindolinone preparation antifungal.
P-Tolylthiosemicarbazide on condensation with 4,5/5,6-dichloroindoline-2,3-diones gave 3-(p-tolylthiosemicarbazono)-4,5/5,6-dichloroindolin-2-ones which on aminomethylation with secondary amines in the presence of formaldehyde gave 1-aminomethyl-3-(p-tolylthiosemicarbazono)-4,5/5,6-dichloroindolin-2-ones. The compounds were screened for their antifungal potential against human pathogenic fungi and their structures were elucidated with the help of elemental anal. and spectral data (1H NMR and Mass).
Indian Journal of Heterocyclic Chemistry published new progress about Fungicides. 1677-47-0 belongs to class indole-building-block, name is 4,5-Dichloroisatin, and the molecular formula is C8H3Cl2NO2, Synthetic Route of 1677-47-0.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles