A flexible route to substituted hydroxy-cyclopentanones from cyclobutanones was written by Heng, Rama;Zard, Samir Z.. And the article was included in Tetrahedron Letters in 2015.Synthetic Route of C11H9NO2 This article mentions the following:
Acetonyl radicals derived from TBS-protected 1-(伪-xanthylacetyl)-1-cyclobutanes readily undergo an addition reaction with un-activated alkenes. Deprotection of the resulting adducts with Et4NF/THF and exposure to silica gel cause ring expansion to give substituted (hydroxy)cyclopentanone derivatives Products of addition to allyl cyanide also underwent 尾-elimination of the xanthate when treated with Et4NF/THF. In the experiment, the researchers used many compounds, for example, 2-Allylisoindoline-1,3-dione (cas: 5428-09-1Synthetic Route of C11H9NO2).
2-Allylisoindoline-1,3-dione (cas: 5428-09-1) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Synthetic Route of C11H9NO2
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles