On February 6, 1986, Henneke, Karl Wilhelm; Wedemeyer, Karlfried published a patent.HPLC of Formula: 52537-00-5 The title of the patent was Procedure for preparing indoline and indoline derivatives. And the patent contained the following:
Indolines I (R1, R2 = H, halo, alkyl, alkoxy; R3 = H, alkyl) were prepared by cyclization of phenethylamines II (X = halo) in the presence of Cu catalysts, characterized in that the cyclization is done in the presence of inorganic carbonates or H carbonates and in the presence of complexing agents for copper ions. Heating a mixture of 2-ClC6H4CH2CH2NH2, CuCl, 8-hydroxyquinoline, soda, and Me2CHCH2OH to boiling and keeping 4-6 h at 120° gave 99.9% pure indoline in 94% yield. Indoline and its derivatives are intermediates for plant protective agents, agrochems., aromas, dyes, and pharmaceuticals. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).HPLC of Formula: 52537-00-5
The Article related to indoline, halophenethylamine cyclization cuprous chelator, plant protective intermediate indoline, agrochem protective intermediate indoline, aroma protective intermediate indoline, dye protective intermediate indoline, pharmaceutical protective intermediate indoline, carbonate cyclization halophenethylamine and other aspects.HPLC of Formula: 52537-00-5
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles