Lactamomethylsilanes – Synthesis, Structures, and Reactivity towards CO2 and Phenyl isocyanate was written by Herbig, Marcus;Boehme, Uwe;Kroke, Edwin. And the article was included in Zeitschrift fuer Anorganische und Allgemeine Chemie in 2019.Electric Literature of C8H7NO This article mentions the following:
Lactamomethylsilanes of 纬-butyrolactam, 未-valerolactam, 蔚-caprolactam, and 1-isoindolinone (phthalimidine) with up to three Me moieties were synthesized according to the chem. formula MexSiLac(4-x) (x = 0, 1, 2, and 3). Using the lactams as starting materials four synthetic routes were tested: salt elimination, transsilylation, transamination, and metalation of the lactames followed by reaction with methylchlorosilanes. All products were analyzed by NMR (1H, 13C and 29Si) and RAMAN spectroscopy. Selected solid products were crystallized and the mol. structure was determined by single-crystal x-ray diffraction. The reactivity of the lactamomethylsilanes towards Ph isocyanate and CO2 was studied. In the experiment, the researchers used many compounds, for example, Isoindolin-1-one (cas: 480-91-1Electric Literature of C8H7NO).
Isoindolin-1-one (cas: 480-91-1) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Electric Literature of C8H7NO
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles