Hlavac, Jan published the artcileSynthesis of oxo analogs of Lamotrigine and related compounds, Safety of 4,5-Dichloroisatin, the main research area is azauracil preparation coupling cyanoacetylcarbamate; Lamotrigine oxo analog preparation; triazinedione functionalized preparation; indolotriazinone preparation.
Lamotrigine oxo analogs I (R1 = H, Cl, Br, iodo, HO) were prepared from azauracil I (R1 = NH2) via the formation of the intermediate diazonium salt. Coupling of this diazonium salt with Et cyanoacetylcarbamate gave the corresponding carbamoyl hydrazone, which underwent intramol. cyclization upon reflux in pyridine to afford bis(triazinyl)benzene II containing two 6-azauracil rings.
ARKIVOC (Gainesville, FL, United States) published new progress about azauracil preparation coupling cyanoacetylcarbamate; Lamotrigine oxo analog preparation; triazinedione functionalized preparation; indolotriazinone preparation. 1677-47-0 belongs to class indole-building-block, name is 4,5-Dichloroisatin, and the molecular formula is C8H3Cl2NO2, Safety of 4,5-Dichloroisatin.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles