On January 31, 2015, Holland, Mareike C.; Meemken, Fabian; Baiker, Alfons; Gilmour, Ryan published an article.Application In Synthesis of H-Idc-OH The title of the article was Chiral imidazolidinone and proline-derived surface modifiers for the Pt-catalyzed asymmetric hydrogenation of activated ketones. And the article contained the following:
A series of imidazolidinone and proline derivatives have been synthesized and tested with regard to their suitability for a chiral modification of platinum used for an asym. hydrogenation of activated ketones. Hydrogenation of ketopantolactone (KPL), Me benzoyl-formate (MBF) and trifluoroacetophenone (TFAP) performed at low hydrogen pressures (1 and 10 bar) were selected as test reactions. With some of these synthetic modifiers, encouraging levels of enantioselectivity were achieved (up to 73.5:26.5 e.r.) without optimization of the reaction conditions. Moreover, performance enhancement of L-proline derived-modifiers, as a consequence of mol. editing with fluorine, was found to be significant (OH é?F, èee up to 23%) contributing to the growing interest in modulating catalyst performance by fluorine introduction. The synthesis of the target compounds was achieved using Engelhard-4759 [i.e., a dihydrocinchonidine-modified 5% platinum-on-alumina catalyst (Engelhard Corp.)] as a catalyst. Chiral modifiers included (8ä¼?9R)-cinchonan-9-ol (cinchonidine), (5S)-2,2,3-trimethyl-5-[(3,4,5-trimethoxyphenyl)methyl]-4-imidazolidinone, (3S)-1-methyl-3-(phenylmethyl)-1,4-diazaspiro[4.4]nonan-2-one, (2S)-ä¼?ä¼?diphenyl-2-pyrrolidinemethanol (proline derivative), (2S)- 2-(fluorodiphenylmethyl)pyrrolidine, (2S)-2,3-dihydro-1H-indole-2-carboxylic acid. Starting materials included activated ketones, such as dihydro-4,4-dimethyl-2,3-furandione (furan-diketone), ä¼?(oxo)benzeneacetic acid Me ester (oxo carboxylic acid ester), 2,2,2-trifluoro-1-(phenyl)ethanone (trifluoromethyl ketone). The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Application In Synthesis of H-Idc-OH
The Article related to hydrogenation stereoselective enantioselective synthesis, Heterocyclic Compounds (One Hetero Atom): Furans and other aspects.Application In Synthesis of H-Idc-OH
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Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles