HPLC of Formula: C7H6O2. I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Synthesis, ADME, docking studies and in vivo anti-hyperglycaemic potential estimation of novel Schiff base derivatives from octadec-9-enoic acid published in 2019.0, Reprint Addresses Kapoor, G (corresponding author), Delhi Inst Pharmaceut Sci & Res, Dept Pharmaceut Chem, New Delhi 110017, India.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde.
A new series of octadec-9-enoic acid schiff base entities (S1-S30) were designed and synthesized targeting peroxisome proliferator activated receptor-gamma for agonist action. Molinspiration software (online) was used to estimate drug like molecular properties of the metabolites. Docking disquisition on co-crystallized protein of PPAR-gamma (PDB ID 1FM9) was carried out which showed S21, S10 and S7 as best situated in the vital sites of receptor having docking scores – 9.19, – 8.68 and – 8.64 respectively. Free binding energy measured using model of Maestro 9.0 and was in range of from – 40.01 and – 80.54 kcal/mol, significant when compared with pioglitazone (- 51.58 Kcal/mol). Seven best docked derivatives were assessed for in-vivo oral glucose tolerance on normal rats and anti-hyperglycaemic activity by streptozotocin induced diabetes model. S21 unveiled to be the best measured analogue among all the synthesized entities. Encouraging outcomes motivates fatty acids for further development of more effective and safer compounds.
Welcome to talk about 100-83-4, If you have any questions, you can contact Kapoor, G; Pathak, DP; Bhutani, R; Husain, A; Jain, S; Iqbal, MA or send Email.. HPLC of Formula: C7H6O2
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles