Recommanded Product: 99-93-4. Recently I am researching about CYSTATHIONINE-BETA-SYNTHASE; PROTEIN SIDE-CHAIN; HYDROGEN-SULFIDE; H2S; ANGIOGENESIS; PARAMETERS; INSIGHTS; POTENT; AMBER, Saw an article supported by the Swiss Krebsliga; Novartis Foundation (Switzerland)Novartis. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Bantzi, M; Augsburger, F; Loup, J; Berset, Y; Vasilakaki, S; Myrianthopoulos, V; Mikros, E; Szabo, C; Bochet, CG. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone
The enzyme 3-mercaptopyruvate sulfurtransferase (3-MST) is one of the more recently identified mammalian sources of H2S. A recent study identified several novel 3-MST inhibitors with micromolar potency. Among those, (2-[(4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]-1-(naphthalen-1-yl)ethan-1-one) or HMPSNE was found to be the most potent and selective. We now took the central core of this compound and modified the pyrimidone and the arylketone sides independently. A 63-compound library was synthesized; compounds were tested for H2S generation from recombinant 3-MST in vitro. Active compounds were subsequently tested to elucidate their potency and selectivity. Computer modeling studies have delineated some of the key structural features necessary for binding to the 3-MST’s active site. Six novel 3-MST inhibitors were tested in cell-based assays: they exerted inhibitory effects in murine MC38 and CT26 colon cancer cell proliferation; the antiproliferative effect of the compound with the highest potency and best cell-based activity (1b) was also confirmed on the growth of MC38 tumors in mice.
Recommanded Product: 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Bantzi, M; Augsburger, F; Loup, J; Berset, Y; Vasilakaki, S; Myrianthopoulos, V; Mikros, E; Szabo, C; Bochet, CG or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles