I found the field of Chemistry very interesting. Saw the article Phosphate linkers with traceable cyclic intermediates for self-immolation detection and monitoring published in 2021.0. Category: indole-building-block, Reprint Addresses Baszczynski, O (corresponding author), Charles Univ Prague, Fac Sci, Prague 12843, Czech Republic.. The CAS is 150-76-5. Through research, I have a further understanding and discovery of Mequinol
Self-immolation (SI) is the key principle of ProTide nucleotide prodrugs such as remdesivir, which is currently used to treat COVID-19 patients. Developing novel tailor-made SI systems requires new analytical methods for the detection and monitoring of SI. We developed a robust method for SI analysis using novel phosphate-based SI linkers with NMR traceable cyclic intermediates to distinguish SI from alternative fragmentation pathways and to monitor cargo release in real time.
Category: indole-building-block. Welcome to talk about 150-76-5, If you have any questions, you can contact Prochazkova, E; Simon, P; Straka, M; Filo, J; Majek, M; Cigan, M; Baszczynski, O or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles