Nickel-catalyzed C3-alkylation of indoles with alcohols via a borrowing hydrogen strategy was written by Hu, Miao;Jiang, Yong;Sun, Nan;Hu, Baoxiang;Shen, Zhenlu;Hu, Xinquan;Jin, Liqun. And the article was included in New Journal of Chemistry in 2021.COA of Formula: C9H9N This article mentions the following:
An efficient method for the Ni-catalyzed C3-alkylation of indoles using readily available alcs. as the alkylating reagents had developed to obtain alkylated indole I [R = H, Me, Ph; R1 = n-Bu, Ph, Bn, etc.; R2 = H, 4-MeC6H4, 6-FC6H4, etc.]. The alkylation was addressed with an air and moisture-stable binuclear nickel complex ligated by tetrahydroquinolin-8-one as the effective pre-catalyst. The newly developed transformation could accommodate a broad substrate scope including primary/secondary benzylic and aliphatic alcs. and substituted indoles. Mechanistic studies suggested that the reaction proceeded through a borrowing hydrogen pathway. In the experiment, the researchers used many compounds, for example, 4-Methyl-1H-indole (cas: 16096-32-5COA of Formula: C9H9N).
4-Methyl-1H-indole (cas: 16096-32-5) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.COA of Formula: C9H9N
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles