Hu, Miao; Jiang, Yong; Sun, Nan; Hu, Baoxiang; Shen, Zhenlu; Hu, Xinquan; Jin, Liqun published their research in New Journal of Chemistry in 2021. The article was titled 《Nickel-catalyzed C3-alkylation of indoles with alcohols via a borrowing hydrogen strategy》.Quality Control of 5-Fluoro-1H-indole The article contains the following contents:
An efficient method for the Ni-catalyzed C3-alkylation of indoles using readily available alcs. as the alkylating reagents had developed to obtain alkylated indole I [R = H, Me, Ph; R1 = n-Bu, Ph, Bn, etc.; R2 = H, 4-MeC6H4, 6-FC6H4, etc.]. The alkylation was addressed with an air and moisture-stable binuclear nickel complex ligated by tetrahydroquinolin-8-one as the effective pre-catalyst. The newly developed transformation could accommodate a broad substrate scope including primary/secondary benzylic and aliphatic alcs. and substituted indoles. Mechanistic studies suggested that the reaction proceeded through a borrowing hydrogen pathway. In the experimental materials used by the author, we found 5-Fluoro-1H-indole(cas: 399-52-0Quality Control of 5-Fluoro-1H-indole)
5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Quality Control of 5-Fluoro-1H-indole
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles