Hu, Ren-Ming; Han, Dong-Yang; Li, Ning; Huang, Jie; Feng, Yu; Xu, Da-Zhen published the artcile< Iron-Catalyzed Direct Oxidative Alkylation and Hydroxylation of Indolin-2-ones with Alkyl-Substituted N-Heteroarenes>, Category: indole-building-block, the main research area is iron catalyzed oxidative oxidative alkylation hydroxylation indolinone alkylheteroarene; N-heteroarenes; cross-coupling; iron; molecular oxygen; oxidation.
Presented herein is the first direct alkylation and hydroxylation reaction between two different C(sp3)-H bonds, indolin-2-ones and alkyl-substituted N-heteroarenes, through an oxidative cross-coupling reaction. The reaction is catalyzed by a simple iron salt under mild ligand-free and base-free conditions. The reaction is environmentally benign, employs air (mol. oxygen) as the terminal oxidant and oxygen source for the synthesis of O-containing compounds, and produces only water as the byproduct. Thus, e.g., indolin-2-one + 2-methylquinoline → I (93%) in presence of Fe(OAc)2.
Angewandte Chemie, International Edition published new progress about Alkylarenes Role: RCT (Reactant), RACT (Reactant or Reagent) (alkyl-substituted N-heteroarenes). 20870-77-3 belongs to class indole-building-block, and the molecular formula is C8H6ClNO, Category: indole-building-block.
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles