Zwitterion-Induced Organic-Metal Hybrid Catalysis in Aerobic Oxidation was written by Hu, Rong-Bin;Lam, Ying-Pong;Ng, Wing-Hin;Wong, Chun-Yuen;Yeung, Ying-Yeung. And the article was included in ACS Catalysis in 2021.Synthetic Route of C8H6N2O2 This article mentions the following:
Herein, an alternative strategy of removing chloride anions from ruthenium trichloride using an organic [P+-N–] zwitterionic compound via multiple hydrogen bond interactions was reported. The resultant organic-metal hybrid catalytic system has successfully been applied to the aerobic oxidation of alcs. such as (E)-cinnamyl alc., 4-methoxybenzyl alc., furfuryl alc., etc.; 1,2,3,4-tetrahydroquinoxaline, and indolines I (R = H, 2-Me, 5-Br, 6-NO2) under mild conditions. The performance of zwitterion is far superior to that of many other common Lewis bases or Bronsted bases. Mechanistic studies revealed that the zwitterion triggers the dissociation of chloride from ruthenium trichloride via nonclassical hydrogen bond interaction. Preliminary studies show that the zwitterion is applicable to catalytic transfer semi-hydrogenation. In the experiment, the researchers used many compounds, for example, 6-Nitro-1H-indole (cas: 4769-96-4Synthetic Route of C8H6N2O2).
6-Nitro-1H-indole (cas: 4769-96-4) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Synthetic Route of C8H6N2O2
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles