Reductive Decarboxylative Alkynylation of N-Hydroxyphthalimide Esters with Bromoalkynes was written by Huang, Liangbin;Olivares, Astrid M.;Weix, Daniel J.. And the article was included in Angewandte Chemie, International Edition in 2017.Category: indole-building-block This article mentions the following:
A new method for the synthesis of terminal and internal alkynes from the Ni-catalyzed decarboxylative coupling of N-hydroxyphthalimide esters and bromoalkynes is presented. This reductive cross-electrophile coupling is the 1st to use a C(sp)-X electrophile, and appears to proceed via an alkynylnickel intermediate. The internal alkyne products were obtained in yields of 41-95% without the need for a photocatalyst, light, or a strong oxidant. The reaction displays a broad scope of carboxylic acid and alkyne coupling partners, and can tolerate an array of functional groups, including carbamate NH, halogen, nitrile, olefin, ketone, and ester moieties. Mechanistic studies suggest that this process does not involve an alkynylmanganese reagent and instead proceeds through Ni-mediated bond formation. In the experiment, the researchers used many compounds, for example, 1,3-Dioxoisoindolin-2-yl 4-phenylbutanoate (cas: 1841512-58-0Category: indole-building-block).
1,3-Dioxoisoindolin-2-yl 4-phenylbutanoate (cas: 1841512-58-0) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Category: indole-building-block
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles