Catalyst-free chemoselective α-sulfenylation/β-thiolation for α,β-unsaturated carbonyl compounds was written by Huang, Xi;Li, Juan;Li, Xiang;Wang, Jiayi;Peng, Yanqing;Song, Gonghua. And the article was included in RSC Advances in 2019.Application of 14204-27-4 This article mentions the following:
A novel, efficient, catalyst-free and product-controllable strategy has been developed for the chemoselective α-sulfenylation/β-thiolation of α,β-unsaturated carbonyl compds R1CH=CHC(O)R2 (R1 = C6H5, furan-2-yl, 2H-1,3-benzodioxol-5-yl, etc.; R2 = CH3, C6H5, 4-FC6H4, etc.). An aromatic sulfur group could be chemoselectively introduced at α- or β-position of carbonyls with different sulfur reagents R3SSR3 (R3 = C6H5, 4-CH3C6H4, 4-CH3OC6H4, 4-FC6H4) under slightly changed reaction conditions. A series of desired products (Z) and (E)-R1CH=C(SPh)C(O)R2 and R1CH(SR3)CH2C(O)R2 were obtained in moderate to excellent yields. Mechanistic studies revealed that B2pin2 played the key role in activating the transformation towards the β-thiolation of α,β-unsaturated carbonyl compounds This transition-metal-catalyst-free method provides a convenient and efficient tool for the highly chemoselective preparation of α-thiolation or β-sulfenylation products of α,β-unsaturated carbonyl compounds In the experiment, the researchers used many compounds, for example, 2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4Application of 14204-27-4).
2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Application of 14204-27-4
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles