Huang, Xu-Lun; Cheng, Yuan-Zheng; You, Shu-Li published an article in , the title of the article was Visible-light enabled synthesis of cyclopropane-fused indolines via dearomatization of indoles.HPLC of Formula: 65417-22-3 And the article contains the following content:
An efficient synthesis of methylene-unsubstituted cyclopropane-fused indolines I (R1 = H, 2-Br, 3-Me, etc.; X = N, CH; R2 = H, CO2Me, Ac, 2-hydroxyethyl; R3 = H, Me; R4 = Boc, Ts, Ac, 4-acetyl-10,10-dimethyl-3-thia-4-azatricyclodecane-3,3-dione) and (R)-1a-((1R,5S)-10,10-dimethyl-3,3-dioxo-3lambda*6*-thia-4-aza-tricyclo[5.2.1.0*1,5*]decane-4-carbonyl)-1a,6a-dihydro-1H-6-aza-cyclopropa[a]indene-6-carboxylic acid tert-Bu ester via photoredox catalyzed dearomative cyclopropanation of indole derivatives II was developed. A broad range of indoles bearing a variety of functional groups was compatible with these mild conditions, affording the products in moderate to excellent yields. Asym. cyclopropanation was also realized with the assistance of a chiral auxiliary in good yield with excellent diastereoselectivity, followed by the removal of the auxiliary to give enantioenriched alc. I. The 5 mmol scale reaction and derivatizations of the products I were successfully carried out to demonstrate the synthetic value of this reaction. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).HPLC of Formula: 65417-22-3
The Article related to cyclopropane indoline preparation diastereoselective, indole preparation iodomethylsilicate dearomative cyclopropanation photoredox catalyst, Placeholder for records without volume info and other aspects.HPLC of Formula: 65417-22-3
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles