Synthetic Route of 66-97-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 66-97-7, Name is Psoralen, SMILES is O=C1C=CC2=C(O1)C=C(OC=C3)C3=C2, belongs to indole-building-block compound. In a article, author is Muhammad, Zeinab A., introduce new discover of the category.
Synthesis and Antitumor Activity of Novel [1,2,4,5]-tetrazepino[6,7-b]indole Derivatives: Marine Natural Product Hyrtioreticuline C and D Analogues
Background: Several biologically active indole alkaloids have been isolated from marine organisms over the previous few years. Many scientsts interested in synthesis of the marine azepinoindole alkaloids due to their wide range of bioliogical activies. Objective: We interested herein to synthesize a new series of some analogues of new naturally occurring azepinoindole alkaloids. Method: A novel series of [1,2,4,5]tetrazepino[6,7-b]indoles, Marine natural product Hyrtioreticuline C and D analogues, were synthesized via the reaction of 3-hydrazonoindolin-2-one with hydrzaonoyl chlorides in basic medium. Results: The spectral data of the products proved their structure. All new derivatives were tested against two carcinoma cell lines ((A-549 & HepG2)) in comparison with the well-known anticancer standard drug (cisplatin) and two derivatives from the tested compounds showed activity more potent than the reference drug. Conclusion: We succeeded in synthesis of new antitumor active azepinoindole alkaloids.
Synthetic Route of 66-97-7, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 66-97-7.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles