Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Liu, Chao, once mentioned the application of 99614-02-5, Name is Ondansetron, molecular formula is C18H19N3O, molecular weight is 293.36, MDL number is MFCD00833882, category is indole-building-block. Now introduce a scientific discovery about this category, Category: indole-building-block.
Differentiating alkyne reactivity in the post-Ugi transformations: Access to polycyclic indole-fused frameworks
The Ugi adducts prepared from propiolic acids, propargylamines, indole-2-carbaldehydes, and isocyanides were utilized to assemble polycyclic indole-fused frameworks via two consecutive carbocyclizations involving triple bonds. First, the peptidyl position of Ugi adduct underwent potassium carbonate-mediated cyclization onto the triple bond derived from propiolic acid. Then, the position 3 of indole core engaged into gold-catalyzed cyclization onto the propargylamine-originated alkyne, completing the construction of polycyclic core. (C) 2018 Elsevier Ltd. All rights reserved.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles