Ishii, Hisashi published the artcileFischer indolization and its related compounds. VIII. Formation of 4-aminoindole derivatives on the Fischer indolization of 2-methoxyphenylhydrazone derivatives, Recommanded Product: Ethyl 7-methoxy-1H-indole-2-carboxylate, the publication is Chemical & Pharmaceutical Bulletin (1974), 22(9), 1981-9, database is CAplus.
Fischer indolization of Et pyruvate 5-chloro-2-methoxyphenylhydrazone with ZnCl2 gave Et 4-amino-6-chloroindole-2-carboxylate (I,R = 4-NH2R1 = 6-Cl) together with I (R = 5-Cl, 5-OMe, R1 = 6-Cl; R = 4-Cl, R1 =7-OMe). Cyclization of Et Pyruvate 2-methoxyphenylhydraxone with p-toluenesulfonic acid in the presence of malonate gave Et 4-(ethoxycarbonylacetamido)indole-2-carboxylate and di-Et 4-(ethoxycarbonylacetamido)-3,6′-biindole-2,2-dicarboxylate with I (R = H, R1 = 5-OMe, 7-OMe,5-O3SC6H4Me-p) and aminoindole product in the abnormal Fisher indolization of a 2-methoxyphenylhydrazone derivative is discussed.
Chemical & Pharmaceutical Bulletin published new progress about 20538-12-9. 20538-12-9 belongs to indole-building-block, auxiliary class Indole,Ester,Ether, name is Ethyl 7-methoxy-1H-indole-2-carboxylate, and the molecular formula is C12H13NO3, Recommanded Product: Ethyl 7-methoxy-1H-indole-2-carboxylate.
Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles