Jang, Ye Jin published the artcileSynthesis and anti-influenza virus activity of 4-oxo- or thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-ones, Application In Synthesis of 220943-23-7, the publication is Antiviral Research (2014), 66-75, database is CAplus and MEDLINE.
A series of dihydrofuropyridinones I (X = O, S; R1 = H, Me; R2 = Me, Ph; R3 = 5-fluoro-3-indolyl, 2-thienyl, 3-furyl, 3-benzothienyl, etc.) has been synthesized under conventional thermal and microwave irradiation conditions. To investigate the structure-activity relationships, two dozens of the hit analogs were synthesized. One of the hit compounds, I (X = S; R1 = H; R2 = Me; R3 = 5-fluoro-3-indolyl), had half-maximal effective concentrations of 17.4-21.1 μM against influenza A/H1N1, A/H3N2 and B viruses without any cellular toxicity at 900 μM. Among the products, I (X = S; R1 = H; R2 = Me; R3 = 2-benzothienyl, 3-thienyl, 2-thienyl, 5-Me-2-thienyl) and I (X = S; R1 = R2 = Me; R3 = 3-Me-2-thienyl) had anti-influenza viral activity comparable or superior to that of the initial hit. Based on a mode-of-action study, these compounds did not affect virus entry or RNA replication. Instead, they suppressed viral neuraminidase activity. This study is the first to demonstrate that dihydrofuropyridinones could serve as lead compounds for the discovery of alternative influenza virus inhibitors.
Antiviral Research published new progress about 220943-23-7. 220943-23-7 belongs to indole-building-block, auxiliary class Indole,Fluoride,Aldehyde, name is 5-Fluoro-1H-indole-2-carbaldehyde, and the molecular formula is C9H6FNO, Application In Synthesis of 220943-23-7.
Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles