Jiang, Fanwei published the artcileSynthesis of substituted indole-3-carboxylic acid derivatives, Category: indole-building-block, the publication is Huaxue Tongbao (2015), 78(4), 378-380, database is CAplus.
Indole-3-carboxylic acid was a kind of important organic intermediate, which could be widely used in the synthesis of medicine and pesticide. Substituted 2-nitro-β-dimethylamino styrene was obtained from the reaction of substituted 2-nitrotoluene and N,N-dimethylformamide di-Me acetal in N,N-dimethylformamide, which was further reacted with iron and acetic acid to give substituted indoles. Five substituted indole-3-carboxylic acids were synthesized from substituted indoles and trifluoroacetic anhydride. The reported synthesis had the advantages of simple post treatment, mild conditions and higher yields.
Huaxue Tongbao published new progress about 10242-03-2. 10242-03-2 belongs to indole-building-block, auxiliary class Indole,Nitro Compound,Carboxylic acid,Indole, name is 6-Nitro-1H-indole-3-carboxylic acid, and the molecular formula is C9H6N2O4, Category: indole-building-block.
Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles