Palladium-catalyzed sequential acylation/annulation of indoles with acyl chlorides using primary amine as the directing group was written by Jiang, Guangbin;Yang, Guang;Liu, Xinqiang;Wang, Shoucai;Ji, Fanghua. And the article was included in New Journal of Chemistry in 2021.Electric Literature of C9H9N This article mentions the following:
An convenient strategy for the direct acylation/annulation of indoles was developed using Pd(0) as an efficient catalyst. The main feature of this protocol was the use of acyl chlorides as the acylating agents with the primary amine as the directing group. A variety of indolo[1,2-a]quinoxalines were readily obtained in reasonable efficiency and satisfactory yields with good functional group tolerance. Based on control experiments, a tentative catalytic mechanism was proposed. In the experiment, the researchers used many compounds, for example, 4-Methyl-1H-indole (cas: 16096-32-5Electric Literature of C9H9N).
4-Methyl-1H-indole (cas: 16096-32-5) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Electric Literature of C9H9N
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles