Jiang, Zhigan published the artcileScaffold hopping of sampangine: discovery of potent antifungal lead compound against Aspergillus fumigatus and Cryptococcus neoformans, Recommanded Product: 4-(Benzyloxy)-1-methyl-1H-indole, the main research area is antifungal sampangine derivative; Antifungal activity; Sampangine; Scaffold hopping.
Discovery of novel antifungal agents against Aspergillus fumigatus and Cryptococcus neoformans remains a significant challenge in current antifungal therapy. Here, the antifungal natural product sampangine (I) was used as the lead compound for novel antifungal drug discovery. D-ring scaffold hopping derivatives were designed and synthesized to improve antifungal activity and water solubility Among them, the thiophene derivative S2 showed broad-spectrum antifungal activity, particularly for Aspergillus fumigatus and Cryptococcus neoformans. Moreover, compound S2 also revealed better water solubility than sampangine, which represents a promising antifungal lead compound for further structural optimization.
Bioorganic & Medicinal Chemistry Letters published new progress about Aspergillus fumigatus. 13523-93-8 belongs to class indole-building-block, name is 4-(Benzyloxy)-1-methyl-1H-indole, and the molecular formula is C16H15NO, Recommanded Product: 4-(Benzyloxy)-1-methyl-1H-indole.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles