Jimenez, Elsie C. et al. published their research in Biochemistry in 1997 | CAS: 52448-17-6

(S)-2-Amino-3-(6-bromo-1H-indol-3-yl)propanoic acid (cas: 52448-17-6) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.SDS of cas: 52448-17-6

Bromocontryphan: post-translational bromination of tryptophan was written by Jimenez, Elsie C.;Craig, A. Grey;Watkins, Maren;Hillyard, David R.;Gray, William R.;Gulyas, Joseph;Rivier, Jean;Cruz, Lourdes J.;Olivera, Baldomero M.. And the article was included in Biochemistry in 1997.SDS of cas: 52448-17-6 This article mentions the following:

The authors demonstrate that post-translational bromination of a tryptophan residue occurs in the biol. active octapeptide bromocontryphan, purified and characterized from Conus radiatus venom. Clones encoding bromocontryphan were identified from a cDNA library made from C. radiatus venom ducts. The mRNA sequence obtained predicts a prepropeptide which has the mature peptide sequence at the C-terminal end, with the L-6-bromotryptophan residue encoded by UGG, the Trp codon. These data provide the first direct evidence for post-translational bromination of a polypeptide which is translated through the normal cellular machinery. In addition to bromination, the peptide, which induces a “stiff tail” syndrome in mice, has several other modifications, including hydroxylation of Pro3, epimerization of Trp4, and C-terminal amidation. Bromocontryphan appears to have the highest d. of post-translational modifications known among gene-encoded polypeptides. The overall result is a mol. which closely resembles marine natural products produced through specialized biosynthetic pathways comprising many enzyme-catalyzed steps. In the experiment, the researchers used many compounds, for example, (S)-2-Amino-3-(6-bromo-1H-indol-3-yl)propanoic acid (cas: 52448-17-6SDS of cas: 52448-17-6).

(S)-2-Amino-3-(6-bromo-1H-indol-3-yl)propanoic acid (cas: 52448-17-6) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.SDS of cas: 52448-17-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles