On August 10, 2006, Jolidon, Synese; Narquizian, Robert; Norcross, Roger, David; Pinard, Emmanuel published a patent.Application of 52537-00-5 The title of the patent was Preparation of heterocyclic substituted phenyl methanones as inhibitors of the glycine transporter 1. And the patent contained the following:
The title compounds I [R1 = halo, cycloalkyl, aryl, etc.; R2 = SO2(alkyl), SO2NH(alkyl), NO2 or CN; het = aromatic or partially aromatic bicyclic amine, which may contain one or two addnl. N-atoms, selected from (un)substituted isoindolyl, indolyl, pyrrolo[3,4-d]pyrimidinyl, etc.], useful for treating illnesses based on the glycine uptake inhibitor, were prepared and formulated. Thus, reacting 2-isopropoxy-5-methansulfonylbenzoic acid (preparation given) with 2,3-dihydro-1H-isoindole afforded 88% II. It has been found that the compounds I are good inhibitors of the glycine transporter 1 (GlyT-1) (IC50 values were given for representative compounds I). The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Application of 52537-00-5
The Article related to heterocyclyl phenyl methanone preparation glycine transporter glyt1 inhibitor, isoindolyl phenyl methanone preparation glycine transporter glyt1 inhibitor, indolyl phenyl methanone preparation glycine transporter glyt1 inhibitor, pyrrolopyrimidinyl phenyl methanone preparation glycine transporter glyt1 inhibitor and other aspects.Application of 52537-00-5
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles