Jones, Hilton Ira et al. published their research in Journal of the American Chemical Society in 1918 | CAS: 24407-32-7

4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Name: 4,5,6,7-Tetrabromoisoindoline-1,3-dione

Preparation of methylamine was written by Jones, Hilton Ira;Wheatley, Roth. And the article was included in Journal of the American Chemical Society in 1918.Name: 4,5,6,7-Tetrabromoisoindoline-1,3-dione This article mentions the following:

A study of the equations given by Werner to explain the mechanism of the reaction between HCHO and NH4Cl shows that if the temperature should be kept down and the decomposition of the HCO2H as It formed should be hastened MeNH2 should be almost the sole product, a deduction which has been verified by experiment Of 4 experiments, one was a duplication of W.’s, the 2nd was a slow distillation like the first but under 20 mm., in the 3rd the material was refluxed 8 hrs. under atm. pressure before the distillation (also under atm. pressure). while in the 4th the refluxing (4.5 hrs.) and distillation were carried out under 20 mm. Working with 150 g. NH4Cl and 300 g. of 40% HCHO, the following results were obtained in the 4 experiments, resp.: unchanged NH4Cl, 46.47, 79.9, 33.5, 27.18; MeNH2Cl, 70.67, 44.83, 67.60, 82.50; Me2NH2Cl, 12.40, 9.66, 17.35, 7.90; non-crystallizing residue, 45.53, 23.53, 64-73, 54.43 g. The sp. gr. and rotations of the distillates and the approx. amounts of HCO2Me and HCO2H present were also determined The results all accord with W.’s theory. In the experiment, the researchers used many compounds, for example, 4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7Name: 4,5,6,7-Tetrabromoisoindoline-1,3-dione).

4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Name: 4,5,6,7-Tetrabromoisoindoline-1,3-dione

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles