Enantioselective Synthesis of Chiral 伪-Alkylthiomalonates via a Phase-Transfer-Catalyzed 伪-Sulfenylation of 伪-Alkylmalonates was written by Jung, So Hyun;Kim, Byungsoo;Park, Cheonhyoung;Kim, Jeongseok;Ha, Min Woo;Hong, Suckchang;Park, Hyeung-geun. And the article was included in Asian Journal of Organic Chemistry in 2019.SDS of cas: 14204-27-4 This article mentions the following:
A synthetic method for accessing chiral 伪-alkylthio-伪-alkylmalonates I (R = allyl, i-Pr, C6H5, etc.) was successfully established. The enantioselective 伪-sulfenylation of 伪-alkylmalonates via phase-transfer catalysis [N-alkylthiophthalimide, 50% aqueous KOH, toluene, -40掳 and N-2′,3′,4′-trifluorophenyl-dihydroquinidium bromide] provided the corresponding 伪-alkylthio-伪-alkylmalonates in high chem. yields (up to 97%) and optical purities (up to 90% ee). In the experiment, the researchers used many compounds, for example, 2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4SDS of cas: 14204-27-4).
2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.SDS of cas: 14204-27-4
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles