Studies on the syntheses of heterocyclic compounds. Part 742. Studies on the syntheses of analgesics. Part 50. Synthesis of optically active 2-[4-(1-oxo-2-isoindolinyl)phenyl]propanoic acid was written by Kametani, Tetsuji;Kigasawa, Kazuo;Hiiragi, Mineharu;Ishimaru, Haruhide;Haga, Seiji;Shirayama, Keiko. And the article was included in Journal of Heterocyclic Chemistry in 1978.Name: 2-Phenylisoindolin-1-one This article mentions the following:
Analgesic and antiinflammatory I (R = CHMeCO2H), prepared from I (R = COMe) (II) via oxidation of I (R = CHMeCOCO2H) (III) or hydrolysis of I (R = Q, R1 = H, R2 = CH), was resolved via diastereoisomeric salts with cinchonidine. III was obtained from II in 5 steps via I [R = CMe:C(CN)CO2Et; Q, where R1 = CO2NH2, R2 = CO2Et and R1 = CONH2, R2 = CO2Na; R = COCONH2] or by Darzens reaction of II with ClCH2CO2Et and treatment of the resulting I (R = Q, R1 = H, R2 = CO2Et) with concentrated HCl and HOAc. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Name: 2-Phenylisoindolin-1-one).
2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Name: 2-Phenylisoindolin-1-one
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles