On December 23, 2009, Kamikubo, Takashi; Miura, Masanori; Okuda, Takao; Maki, Keisuke; Hirayama, Fukushi; Moritomo, Ayako; Komiya, Yuriko; Matsuura, Keisuke; Ibuka, Ryotaro published a patent.SDS of cas: 52537-00-5 The title of the patent was Preparation of 2-pyridone derivatives as EP4 receptor agonists for treatment of peripheral arterial disease. And the patent contained the following:
The title compounds I [wherein L1 and L2 = independently alkylene, alkenylene, etc.; R1 = substituted aryl or heteroaryl; R2 = (un)substituted alkylamino, heteroarylamino, etc.; R3 – R5 = independently H, halo, CN, alkyl, etc.] or pharmaceutically acceptable salts thereof are prepared as prostanoid receptors type EP4 (EP4) inhibitors for the treatment of peripheral arterial disease. For example, the compound II was prepared in a multi-step synthesis. II inhibited EP4 receptor with IC50 value of 0.52 nM in rat. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).SDS of cas: 52537-00-5
The Article related to pyridone preparation prostanoid receptor agonist treatment peripheral arterial disease, prostanoid receptor ep4 agonist preparation pyridone, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.SDS of cas: 52537-00-5
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles