Molecular docking study on approved drugs against treatment of SARS-CoV-2 pandemic: a drug repurposing study was written by Kapish, Kapoor;Aman, Mourya;Yuvraj, Patidar;Shoyab, Khan Md.;Nayan, Shroff;Aayushi, Kavishwar. And the article was included in World Journal of Pharmaceutical Research in 2020.Application In Synthesis of (-)-1-(3-Hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-2,3-di-hydro-1H-indole-7-carboxamide This article mentions the following:
COVID-19(corona virus disease -19) is a viral flu which is caused by SARS-CoV-2(severe acute respiratory syndrome corona virus 2) has affected more than 1.5 million people around the world. Currently there are 19 different ways to tackle this pandemic approved by USFDA, one of it is drug repurposing or positioning of current existing drugs. In this study more than 1800 mols. approved by the USFDA were chosen for the mol. docking studies. These mols. were docked on PDB code; 6LU7 (The crystal structure of COVID-19 main protease in complex with an inhibitor N3) using Molegro virtual docker version 6.0.1 . The study helped in identifying HITS and further in vitro and in-vivo studies of the selected HITS can be studied for their therapeutic potential in treating COVID-19. In the experiment, the researchers used many compounds, for example, (-)-1-(3-Hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-2,3-di-hydro-1H-indole-7-carboxamide (cas: 160970-54-7Application In Synthesis of (-)-1-(3-Hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-2,3-di-hydro-1H-indole-7-carboxamide).
(-)-1-(3-Hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-2,3-di-hydro-1H-indole-7-carboxamide (cas: 160970-54-7) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Application In Synthesis of (-)-1-(3-Hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-2,3-di-hydro-1H-indole-7-carboxamide
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles