Design, synthesis, anticancer activity, molecular docking and ADME studies of novel methylsulfonyl indole-benzimidazoles in comparison with ethylsulfonyl counterparts was written by Karadayi, Fikriye Zengin;Yaman, Murat;Kisla, Mehmet Murat;Konu, Ozlen;Ates-Alagoz, Zeynep. And the article was included in New Journal of Chemistry in 2021.Name: 5-Chloroindole-3-carboxaldehyde This article mentions the following:
In this study, novel methylsulfonyl indole-benzimidazole derivatives I (R1 = Me, cyclohexyl, (3,4-dichlorophenyl)methyl, etc.; R2 = H, OMe, Cl, Br) have been synthesized upon substitution of resp. first (R1) and fifth (R2) positions of benzimidazole and indole groups. Structure and activity relationships were then studied via 1H NMR, 13C NMR, mass spectral and in silico docking analyses, as well as cell viability measurements. The compounds I that exhibited substantial affinity levels towards ER alpha (ER婵? were found. In addition, the correlation anal. of cytotoxicity profiles between ethyl- and methyl-sulfonyl indole-benzimidazoles revealed a collection of effective and consistent R1 and R2 substitutions. However, for some candidate derivatives, I distinctive cytotoxicity levels and varying viability vs. ER婵?affinity correlations were observable across the studies, suggesting that the sulfonyl side chain modifications themselves can also influence the ER婵?binding levels. These results demonstrated that novel methylsulfonyl indole-benzimidazole derivatives, I similar to their ethylsulfonyl counterparts, exhibit anticancer effects with potential estrogen receptor modulatory actions. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Name: 5-Chloroindole-3-carboxaldehyde).
5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Name: 5-Chloroindole-3-carboxaldehyde
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Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles