Karishin, A. P.’s team published research in Zhurnal Obshchei Khimii in 34 | CAS: 2642-37-7

Zhurnal Obshchei Khimii published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, HPLC of Formula: 2642-37-7.

Karishin, A. P. published the artcileCondensation of 5-chloro-6-fluoroacenaphthenequinone with 3-hydroxythionaphthene, its derivatives, and indoxyl, HPLC of Formula: 2642-37-7, the publication is Zhurnal Obshchei Khimii (1964), 34(9), 306-8, database is CAplus.

Indigoid dyes of structure I were prepared, where X is S or NH, R1 is H or Me, R2 is H, or R1 + R2 is benzo, and R3 is H, Cl, or OEt. 5-Chloro-6- fluoroacenaphthene (10 g.) in 150 ml. HOAc was heated to 100掳, 50 g. Na2Cr2O7 was added, heating continued 4 min., and the mixture poured into 300 ml. H2O. The precipitate was filtered, washed, and heated twice with 300 ml. 6% NaHC03 solution on a boiling water bath for 40 min. 4,5,1,8-ClFC10H4(CO2H)2 (II), precipitated by acidifying the alk. solution with HCl, was filtered and dried to yield 3.1 g. colorless needles of II anhydride (III), m. 234-5掳 (HOAc). The filtrate from the isolation of III was treated twice with 50 ml. 25% NaHSO3. The resulting compound was decomposed with HCl, and the mixture was boiled to remove SO2, then cooled, filtered, and dried to give 3.41 g. 5-chloro-6-fluoronaphthenequinone (IV) golden yellow needles, m. 241-2. To 0.01 mole IV in 50 ml. boiling HOAc were added 0.01 mole 3-hydroxythionaphthene and 5 drops concentrated HCl, and the mixture was boiled 5 min., cooled, and filtered to give 88.2% I (R1 = R2 = R3 = H, X = S), m. 284-5掳(PhNO2)2, 位max. 492 and 535 m渭. Other I (X = S) were prepared similarly (R1, R2, R3, % yield, m.p., and 位max in 渭 (PhCl) given): H, H, Cl, 81.5, 375-6掳, 480 and 515; Me, H, Cl, 77.3, 334-5%, 482 and 517; H, H, OEt, 61.2, 271-2掳 460 and 496; R1 + R2 = benzo, H, 61.5, 337-8掳, 464 and 510. To 2.34 g. IV in 50 ml. boiling HOAc was added a filtered solution of 18.6 g. 7% indoxyl melt in 60 ml. 70% HOAc. The mixture was boiled 5 min., then cooled to give 2.6 g. (74.4%) I (R1 = R2 = R3 = H, X = NH), m. 324-5掳 (PhNO2), 位max 552 and 571 m渭.

Zhurnal Obshchei Khimii published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, HPLC of Formula: 2642-37-7.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles